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KMID : 0355620150410010011
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2015 Volume.41 No. 1 p.11 ~ p.18
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Expression of vascular endothelial growth factor in oral squamous cell carcinoma
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Kim Seok-Kon
Park Seung-Goo
Kim Kyung-Wook
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Abstract
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Objectives: The goal of this study was to determine the correlation of clinicopathological factors and the up-regulation of vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma.
Materials and Methods: Immunohistochemical staining of VEGF and quantitative real-time polymerase chain reaction (RT-PCR) of VEGF mRNA were performed in 20 specimens from 20 patients with oral squamous cell carcinoma and another 20 specimens from 20 patients with carcinoma in situ as a controlled group.
Results: The results were as follows: 1) In immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, high-level staining of VEGF was observed. Significantcorrelation was observed between immunohistochemical VEGF expression and histologic differentia-tion, tumor size of specimens (Pearson correlation analysis, significancer>0.6, P<0.05). 2) In VEGF quantitative RT-PCR analysis, progressive cancer showed more VEGF expression than carcinoma in situ. Paired-samples analysis determined the difference of VEGF mRNA expression level between cancer tissue and carcinoma in situ tissue, between T1 and T2-4 (Student’s t-test, P<0.05).
Conclusion: These fndings suggest that up-regulation of VEGF may play a role in the angiogenesis and progression of oral squamous cell carcinoma.
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KEYWORD
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Squamous cell carcinoma, Vascular endothelial growth factor, Real-time polymerase chain reaction, Immunohistochemistry
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